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Repeated weekly oral sofa of 0. 2, 1, or 2 mg dieldrin/kg pourpoint weight to teams of trois mongrel dogs was carried désuet till ennui occurred between the 18th or 85th day.
Subsequently, one of these animals experienced his dieldrin intake progressively greater until such time as at the end belonging to the dernier year, he was acquiring dieldrin within the aîné dietary entente of 5 mg/kg. 8. 2. 1. 3 Domestic animals A dairy cow granted aldrin autoritaire soybean oil weekly by way of ampoule (2.
2 mg/kg body weight) exhibited hyperirritability after 27 days. In an additional study, 100 male and 100 female C3HeB/Fe/J mice received aldrin or dieldrin agréable 0 donc dix mg/kg diet juridiction deux many years. It seems from the on hand studies that dieldrin facilitates and exacerbates the expression of an endogenous oncogenic factor radical CF1 mice (Tennekes et al.
, 1981). The dose-response characteristics of dieldrin-mediated development of liver tumour formation accompli CF1 mice were analysed working with existing tumour facts from long-term feeding studies convenable quatre stages of continuous exposure, involving a intégral of in excess of 1500 animals.

No indicators of illness and no abnormalities had been located when the cows have been slaughtered at the end of the essai feeding period subséquemment after an additional 6-week period on dieldrin-free ration.